The dynamics of Native American female leadership is becoming a more prevalent topic in the scholarly literature as more educated Native American women become visible in tribal higher education. This qualitative case study explored Native American female leadership, as a growing number of Native American women enter higher education and earn doctorates. The research explored the opportunities and challenges that have influenced Native American women who are leaders in Tribal Colleges and Universities, the significance they place on their culture and heritage as leaders, their roles in policy and institutional change, and their perspectives regarding their leadership roles. The study revealed many aspects of Native American female leadership in higher education and how it interfaces with Native American culture. Participants' stories revealed that the development of leadership skills for Native American women is rooted in the oral traditions of Native American culture. The cultural makeup of the participants was varied and extraordinary; this group of Native American women shared their individual stories and journeys to leadership in tribal higher education so that Native American women and others who aspire to become leaders can benefit from their experiences. All participants agreed that tribal politics, curriculum development, providing authentic cultural learning experiences, and tribal sovereignty are challenges for the continuing development of Tribal Colleges and Universities. The leadership styles and approaches were as diverse as the group of unique and individual participants. However, one resounding aspect of their leadership is the importance of maintaining cultural identity, oral traditions, and heritage, which participants agreed are the foundation for developing professional and personal leadership skills. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]