ERIC Number: EJ1008400
Record Type: Journal
Publication Date: 2013-May
Abstractor: As Provided
Diurnal Cortisol Profile in Williams Syndrome in Novel and Familiar Settings
Lense, Miriam Diane; Tomarken, Andrew J.; Dykens, Elisabeth M.
American Journal on Intellectual and Developmental Disabilities, v118 n3 p201-210 May 2013
Williams syndrome (WS) is a neurodevelopmental genetic disorder associated with high rates of anxiety and social issues. We examined diurnal cortisol, a biomarker of the stress response, in adults with WS in novel and familiar settings, and compared these profiles to typically developing (TD) adults. WS and TD participants had similar profiles in a familiar setting, while participants with WS had elevated cortisol late in the day in the novel setting when social demands were higher. The cortisol awakening response in WS was associated with parent-reported levels of somatic complaints and social difficulties. Results suggest that adults with WS have a typical diurnal cortisol profile that may be sensitive to social and activity transitions throughout the day.
Descriptors: Novelty (Stimulus Dimension), Metabolism, Familiarity, Genetic Disorders, Neurological Impairments, Social Development, Anxiety, Stress Variables, Adults, Comparative Analysis
American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A