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Showing 1 to 15 of 155 results Save | Export
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Raboh, Ghada – Journal of Chemical Education, 2018
A high performance liquid chromatography (HPLC) experiment for the upper level analytical chemistry laboratory is described. The students consider the effect of mobile-phase composition and pH on the retention times of ionizable compounds in order to determine the acid dissociation constant, K[subscript a], of a phenolic acid. Results are analyzed…
Descriptors: Science Instruction, College Science, Undergraduate Study, Inquiry
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Betts, Thomas A.; Palkendo, Julie A. – Journal of Chemical Education, 2018
This laboratory experiment employs an innovative approach to introduce undergraduates to liquid chromatography-tandem mass spectrometry (LC-MS/MS) by developing a method based on multiple reaction monitoring (MRM). During this qualitative investigation, students operated a triple quadrupole mass spectrometer in the MS scan and product ion scan…
Descriptors: Undergraduate Students, Science Instruction, Science Laboratories, Laboratory Procedures
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Stankus, Brian; White, Rosemary; Abrams, Binyomin – Journal of Chemical Education, 2019
Chromatography is a ubiquitous technique in analytical chemistry, and high-performance liquid chromatography (HPLC) is the industry standard for quantitation of components in solution mixtures. However, demonstrating the principles of liquid chromatography to undergraduates via HPLC-based experiments often proves ineffective because of the fully…
Descriptors: Chemistry, Science Instruction, College Science, Undergraduate Study
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Lee, Jisun; Schmink, Jason R.; Berritt, Simon – Journal of Chemical Education, 2020
A contemporary undergraduate laboratory experiment incorporating parallel microscale experimentation was developed for the well-defined palladium catalyzed Suzuki-Miyaura cross coupling of 4-fluorophenylboronic acid with both 4-chloro- and 4-bromoanisole using 11 diverse phosphine ligands and one ligandless control. This laboratory introduces…
Descriptors: College Science, Science Instruction, Undergraduate Study, Science Laboratories
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Yang, Rong; Hu, Yang Y.; Huang, Si; Fang, Zheng F.; Ma, Ming; Chen, Bo – Journal of Chemical Education, 2020
A comprehensive experiment for third-year undergraduate students in pharmaceutical engineering is described. Students had previously completed courses in analytical chemistry, chemistry of natural products, and bioseparation engineering and had background knowledge in purification, quantitative analysis, packed column chromatography,…
Descriptors: Chemistry, Science Instruction, Laboratory Experiments, Teaching Methods
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Manninen, Marianna; Vesterinen, Veli-Matti; Salminen, Juha-Pekka – Journal of Chemical Education, 2020
The autumnal leaf color change is a familiar phenomenon to most students living in temperate climate zones. The extraction and analysis of the pigments of the autumn leaves provide an engaging way to study the phenomenon utilizing both simple as well as more sophisticated analytical methods. In this laboratory experiment, students extract the red…
Descriptors: Chemistry, Laboratory Experiments, Spectroscopy, Hands on Science
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Usher, Karyn M.; Simmons, Carolyn R.; Keating, Daniel W.; Rossi, Henry F., III – Journal of Chemical Education, 2015
Chemical separations are an important part of an undergraduate chemistry curriculum. Sophomore students often get experience with liquid-liquid extraction in organic chemistry classes, but liquid-liquid extraction is not as often introduced as a quantitative sample preparation method in honors general chemistry or quantitative analysis classes.…
Descriptors: Science Instruction, College Science, Undergraduate Study, Chemistry
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Frey, Douglas D.; Guo, Hui; Karnik, Nikhila – Chemical Engineering Education, 2013
This article describes the assembly of a simple, low-cost, high-performance liquid chromatography (HPLC) system and its use in the undergraduate chemical engineering laboratory course to perform simple experiments. By interpreting the results from these experiments students are able to gain significant experience in the general method of…
Descriptors: Science Instruction, Chemistry, Chemical Engineering, Science Laboratories
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Boyce, Mary C.; Lawler, Nathan G.; Tu, Yingqi; Reinke, Stacey N. – Journal of Chemical Education, 2019
Metabolomics is the data-driven science of small molecules. Untargeted metabolomics, using liquid chromatography-high resolution mass spectrometry (LC-HRMS), differs greatly from targeted metabolite assays, using nominal mass LC-MS instruments, as it generates thousands of metabolite features which are not quantified and are identified "post…
Descriptors: College Science, Undergraduate Students, Metabolism, Molecular Biology
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Parker, Patrick D.; Beers, Brandon; Vergne, Matthew J. – Journal of Chemical Education, 2017
Laboratory experiments were developed to introduce students to the quantitation of drugs of abuse by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Undergraduate students were introduced to internal standard quantitation and the LC-MS/MS method optimization for cocaine. Cocaine extracted from paper currency was…
Descriptors: Undergraduate Students, Chemistry, Laboratory Experiments, Cocaine
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Nahra, Fady; Riant, Olivier – Journal of Chemical Education, 2015
A modified total synthesis of (S)-goniothalamin is described for an advanced course in organic chemistry. This experiment gives students an opportunity to handle organometallic reagents and perform an enzymatic kinetic resolution and a metathesis reaction, all in the same synthesis. Furthermore, students learn flame-drying techniques for the…
Descriptors: Cancer, Synthesis, Organic Chemistry, Science Experiments
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Alneyadi, Aysha; Shah, Iltaf; Ashraf, Syed Salman – Biochemistry and Molecular Biology Education, 2019
Active-learning strategies such as undergraduate research courses and course-based undergraduate research experiences (CUREs), which engage students in the practical experiments, have been reported as efficient ways for effective teaching and training of graduating students. Recently, many practical examples have been published in various fields…
Descriptors: Research Projects, Undergraduate Students, Active Learning, Student Research
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Leacock, Rachel E.; Stankus, John J.; Davis, Julian M. – Journal of Chemical Education, 2011
A high-performance liquid chromatography experiment to determine the concentration of caffeine and vitamin B6 in sports energy drinks has been developed. This laboratory activity, which is appropriate for an upper-level instrumental analysis course, illustrates the standard addition method and simultaneous determination of two species. (Contains 1…
Descriptors: Chemistry, Science Experiments, Laboratory Experiments, College Science
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Martí-Andre´s, P.; Escuder-Gilabert, L.; Martín-Biosca, Y.; Sagrado, S.; Medina-Herna´ndez, M.J. – Journal of Chemical Education, 2015
Energy drinks, as familiar consumer products, have been widely used in laboratory courses to help promote student interest, as well as to connect lecture concepts with laboratory work. Energy drinks contain B vitamins: pyridoxine (vitamin B6) and riboflavin (vitamin B2) of which amounts are high enough to be of concern. In this work, a fast and…
Descriptors: Science Instruction, Science Experiments, Science Laboratories, Laboratory Experiments
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Baldwin, Bruce W.; Kuntzleman, Thomas S. – Journal of Chemical Education, 2018
The separation of chamazulene from hydrophilic contaminants present in blue tansy oil provides a visually engaging example of two common techniques: extraction and thin-layer chromatography (TLC). This application uses liquid CO[subscript 2] as a lipophilic solvent to pull a brilliant blue hydrocarbon molecule, chamazulene, out of or through a…
Descriptors: Science Instruction, Science Laboratories, College Science, Organic Chemistry
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