ERIC Number: EJ743049
Record Type: Journal
Publication Date: 2006
Reference Count: 0
Mortality in Prader-Willi Syndrome
Einfeld, Stewart L.; Kavanagh, Sophie J.; Smith, Arabella; Evans, Elizabeth J.; Tonge, Bruce J.; Taffe, John
American Journal on Mental Retardation, v111 n3 p193-198 2006
Persons with Prader-Willi syndrome have been known to have a high mortality rate. However, intellectual disability, which usually accompanies Prader-Willi syndrome, is also associated with a higher mortality rate than in the general population. In this study, the death rates in a longitudinal cohort of people with Prader-Willi syndrome are compared with those for an epidemiologically derived control sample of people with intellectual disability from other causes. We found that those with Prader-Willi syndrome had a higher mortality rate than did controls. After the protective effect of mild intellectual disability or average intellectual function was accounted for, the hazard ratio for Prader-Willi syndrome versus controls was 6.07. Obesity and its complications were factors contributing to the mortality identified in this study.
Descriptors: Death, Mild Mental Retardation, Mortality Rate, Obesity, Comparative Analysis, Longitudinal Studies, Genetics, At Risk Persons
American Association on Mental Retardation. P.O. Box 7065, Lawrence, KS 66044-7065. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aamr.org/Periodicals/index.shtml.
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A