Teaching in the digital age has become increasingly challenging for college and university faculty. Application, relevance, and active engagement rather than traditional PowerPoint slide show lectures are what our technology-savvy, socially networked students crave and need to keep their attention and interest levels high. Using a combination of information gathered from brain research and the brain-based teaching and learning literature, direct classroom application of brain-compatible teaching strategies, and student opinion poll data, the authors developed a core of 10 brain-based teaching and learning strategies with real-world examples for college and university level faculty.