ERIC Number: EJ1073009
Record Type: Journal
Publication Date: 2015-Sep
Abstractor: As Provided
Does Autism Diagnosis Age or Symptom Severity Differ among Children According to Whether Assisted Reproductive Technology Was Used to Achieve Pregnancy?
Schieve, Laura A.; Fountain, Christine; Boulet, Sheree L.; Yeargin-Allsopp, Marshalyn; Kissin, Dmitry M.; Jamieson, Denise J.; Rice, Catherine; Bearman, Peter
Journal of Autism and Developmental Disorders, v45 n9 p2991-3003 Sep 2015
Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.
Descriptors: Clinical Diagnosis, Age Differences, Autism, Severity (of Disability), Symptoms (Individual Disorders), Correlation, Pregnancy, Socioeconomic Status, Technological Advancement, Children, Statistical Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institutes of Health (DHHS); National Institute of Mental Health (DHHS/NIH)
Authoring Institution: N/A
Identifiers - Location: California
Grant or Contract Numbers: DP1 OD003635-01|R21MH096122