ERIC Number: EJ1123329
Record Type: Journal
Publication Date: 2017-Jan
Abstractor: As Provided
Primary Auditory Cortex Regulates Threat Memory Specificity
Wigestrand, Mattis B.; Schiff, Hillary C.; Fyhn, Marianne; LeDoux, Joseph E.; Sears, Robert M.
Learning & Memory, v24 n1 p55-58 Jan 2017
Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKM? inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination.
Descriptors: Memory, Brain Hemisphere Functions, Stimuli, Generalization, Auditory Perception, Animals, Prediction, Learning Processes, Anxiety Disorders, Auditory Discrimination, Drug Therapy
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A