ERIC Number: EJ1141315
Record Type: Journal
Publication Date: 2017-Jun
Abstractor: As Provided
Reference Count: 56
A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
Sokolova, Elena; Oerlemans, Anoek M.; Rommelse, Nanda N.; Groot, Perry; Hartman, Catharina A.; Glennon, Jeffrey C.; Claassen, Tom; Heskes, Tom; Buitelaar, Jan K.
Journal of Autism and Developmental Disorders, v47 n6 p1595-1604 Jun 2017
Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD.
Descriptors: Autism, Pervasive Developmental Disorders, Causal Models, Mediation Theory, Attention Deficit Hyperactivity Disorder, Comorbidity, Symptoms (Individual Disorders), Children, Siblings, Structural Equation Models, Self Control, Behavior Problems, Repetition, Attention Control, Comprehension, Verbal Ability, Intelligence Quotient, Physiology, Interpersonal Competence
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institute of Mental Health (DHHS/NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R01MH6287301A1