This article describes a treatment for addictions, based on the idea that addiction is a response to living a life that has little personal meaning. First, it presents the theory of Meaning-Centered Therapy (MCT) as developed by Paul Wong, particularly the need to understand intoxication from the addict's perspective. Next, it presents the principles governing clinical application. MCT is a positive, existential psychotherapy, which incorporates psychoeducational, cognitive-behavioral, narrative, and positive psychologies, by using personal meaning as an organizing construct. The article ends with a case study.