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Showing 1 to 15 of 1,205 results Save | Export
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Ozubko, Jason D.; Moscovitch, Morris; Winocur, Gordon – Learning & Memory, 2017
Prior representations affect future learning. Little is known, however, about the effects of recollective or familiarity-based representations on such learning. We investigate the ability to reuse or reassociate elements from recollection- and familiarity-based associations to form new associations. Past neuropsychological research suggests that…
Descriptors: Recall (Psychology), Familiarity, Brain Hemisphere Functions, Hypothesis Testing
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Solopchuk, Oleg; Alamia, Andrea; Olivier, Etienne; Zénon, Alexandre – Learning & Memory, 2016
Chunking, namely the grouping of sequence elements in clusters, is ubiquitous during sequence processing, but its impact on performance remains debated. Here, we found that participants who adopted a consistent chunking strategy during symbolic sequence learning showed a greater improvement of their performance and a larger decrease in cognitive…
Descriptors: Cognitive Processes, Short Term Memory, Sequential Learning, Symbolic Learning
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Diviney, Mairead; Fey, Dirk; Commins, Sean – Learning & Memory, 2013
Learning to navigate toward a goal is an essential skill. Place learning is thought to rely on the ability of animals to associate the location of a goal with surrounding environmental cues. Using the Morris water maze, a task popularly used to examine place learning, we demonstrate that distal cues provide animals with distance and directional…
Descriptors: Cues, Learning Processes, Task Analysis, Animals
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Yang, Qizong; Antonov, Igor; Castillejos, David; Nagaraj, Anagha; Bostwick, Caleb; Kohn, Andrea; Moroz, Leonid; Hawkins, Robert D. – Learning & Memory, 2018
Long-term but not short-term memory and synaptic plasticity in many brain areas require neurotrophin signaling, transcription, and epigenetic mechanisms including DNA methylation. However, it has been difficult to relate these cellular mechanisms directly to behavior because of the immense complexity of the mammalian brain. To address that…
Descriptors: Memory, Animals, Genetics, Brain
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Dulka, Brooke N.; Ford, Ellen C.; Lee, Melissa A.; Donnell, Nathaniel J.; Goode, Travis D.; Prosser, Rebecca; Cooper, Matthew A. – Learning & Memory, 2016
Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increases the expression of mBDNF, but not proBDNF, in…
Descriptors: Brain, Memory, Brain Hemisphere Functions, Social Behavior
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Es-seddiqi, Mouna; El Massioui, Nicole; Samson, Nathalie; Brown, Bruce L.; Doyère, Valérie – Learning & Memory, 2016
The amygdalo-nigrostriatal (ANS) network plays an essential role in enhanced attention to significant events. Interval timing requires attention to temporal cues. We assessed rats having a disconnected ANS network, due to contralateral lesions of the medial central nucleus of the amygdala (CEm) and dopaminergic afferents to the lateral striatum,…
Descriptors: Time, Cues, Animal Behavior, Animals
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Kosaki, Yutaka; Poulter, Steven L.; Austen, Joe M.; McGregor, Anthony – Learning & Memory, 2015
In three experiments, the nature of the interaction between multiple memory systems in rats solving a variation of a spatial task in the water maze was investigated. Throughout training rats were able to find a submerged platform at a fixed distance and direction from an intramaze landmark by learning a landmark-goal vector. Extramaze cues were…
Descriptors: Neurological Impairments, Animals, Navigation, Spatial Ability
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Mei, Hao; Logothetis, Nikos K.; Eschenko, Oxana – Learning & Memory, 2018
Spatial navigation depends on the hippocampal function, but also requires bidirectional interactions between the hippocampus (HPC) and the prefrontal cortex (PFC). The cross-regional communication is typically regulated by critical nodes of a distributed brain network. The thalamic nucleus reuniens (RE) is reciprocally connected to both HPC and…
Descriptors: Spatial Ability, Brain Hemisphere Functions, Animals, Memory
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Childs, Jessica E.; DeLeon, Jaime; Nickel, Emily; Kroener, Sven – Learning & Memory, 2017
Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction learning reduces rates of relapse. Here we used vagus nerve stimulation (VNS) to induce targeted synaptic…
Descriptors: Cocaine, Genetics, Drug Use, Drug Abuse
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Boisselier, Lise; Ferry, Barbara; Gervais, Rémi – Learning & Memory, 2017
The hippocampal formation has been extensively described as a key component for object recognition in conjunction with place and context. The present study aimed at describing neural mechanisms in the hippocampal formation that support olfactory-tactile (OT) object discrimination in a task where space and context were not taken into account. The…
Descriptors: Animals, Role, Brain Hemisphere Functions, Olfactory Perception
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Wu, Yanying; Ren, Qingzhong; Li, Hao; Guo, Aike – Learning & Memory, 2012
Reversal learning has been widely used to probe the implementation of cognitive flexibility in the brain. Previous studies in monkeys identified an essential role of the orbitofrontal cortex (OFC) in reversal learning. However, the underlying circuits and molecular mechanisms are poorly understood. Here, we use the T-maze to investigate the neural…
Descriptors: Learning, Brain, Olfactory Perception, Entomology
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Kondo, Makoto; Nakamura, Yukiko; Ishida, Yusuke; Yamada, Takahiro; Shimada, Shoichi – Learning & Memory, 2014
The 5-HT [subscript 3] receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT [subscript 3A] receptor knockout mice in fear conditioning paradigms revealed that the 5-HT [subscript 3A]…
Descriptors: Fear, Memory, Cognitive Psychology, Cognitive Processes
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Leaderbrand, Katherine; Chen, Helen J.; Corcoran, Kevin A.; Guedea, Anita L.; Jovasevic, Vladimir; Wess, Jurgen; Radulovic, Jelena – Learning & Memory, 2016
Understanding how episodic memories are formed and retrieved is necessary if we are to treat disorders in which they malfunction. Muscarinic acetylcholine receptors (mAChR) in the hippocampus and cortex underlie memory formation, but there is conflicting evidence regarding their role in memory retrieval. Additionally, there is no consensus on…
Descriptors: Memory, Recall (Psychology), Brain Hemisphere Functions, Pharmacology
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Peters, Jamie; Scofield, Michael D.; Reichel, Carmela M. – Learning & Memory, 2018
Prolonged use of methamphetamine (meth) has been associated with episodic memory deficits in humans, and preclinical rat models of meth self-administration indicate the memory deficits are a consequence of meth use. Others have suggested that the meth-induced memory deficits may promote a cyclical pattern of drug use, abstinence, and relapse,…
Descriptors: Drug Abuse, Memory, Brain Hemisphere Functions, Animals
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Kleber, Jörg; Chen, Yi-Chun; Michels, Birgit; Saumweber, Timo; Schleyer, Michael; Kähne, Thilo; Buchner, Erich; Gerber, Bertram – Learning & Memory, 2016
Synapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the "Drosophila" genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function…
Descriptors: Associative Learning, Genetics, Scores, Short Term Memory
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