ERIC Number: EJ744270
Record Type: Journal
Publication Date: 2006
Reference Count: 0
The Effect of Acetyl-L-Carnitine Administration on Persons with Down Syndrome
Pueschel, Siegfried M.
Research in Developmental Disabilities: A Multidisciplinary Journal, v27 n6 p599-604 Nov-Dec 2006
Since previous investigations reported improvements in cognition of patients with dementia after acetyl-L-carnitine therapy and since there is an increased risk for persons with Down syndrome to develop Alzheimer disease, this study was designed to investigate the effect of acetyl-L-carnitine administration on neurological, intellectual, and social functions in adults with Down syndrome. In this double-blind study we enrolled 40 individuals with Down syndrome and administered acetyl-L-carnitine to the study group during a six months period. Specified examinations and psychological tests were given to persons in both the study and control groups at the start of the investigation and at 3, 6, and 9 months. A detailed analysis of the data revealed that acetyl-L-carnitine administration did not enhance central nervous system functions and that it did not benefit persons with Down syndrome.
Descriptors: Down Syndrome, Alzheimers Disease, Adults, Psychological Testing, Patients, Dementia, At Risk Persons, Outcomes of Treatment, Molecular Biology, Cognitive Ability, Interpersonal Competence, Psychological Patterns, Neurological Impairments, Comparative Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A