Neuroscience continues to enjoy a renaissance of study and a range of responses, both in explorations of religious experience and in educational practice. Neuroscience, as an interdisciplinary field, attained a new ascendancy at the end of the 20th century, known as the decade of the brain. New insights continue to influence education and public policy, in the following ten years. The explosion of neuroscientific insights offers numerous opportunities to religious educators, inviting ongoing creativity in the midst of diverse issues and opportunities. The author contends that religious educators can benefit from these insights, and contribute as well. Moreover, issues continue to surface in relation to neuroscience and religious expression. In class discussions the author's students have noted how many discoveries in neuroscience yields additional ethical issues for ministers and educators. Learning to respond to these issues creatively and respectfully offers one additional challenge.