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ERIC Number: EJ1142283
Record Type: Journal
Publication Date: 2017-Jun
Pages: 5
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1072-0502
Long-Term Sensitization Training in "Aplysia" Decreases the Excitability of a Decision-Making Neuron through a Sodium-Dependent Mechanism
Hernandez, John S.; Wainwright, Marcy L.; Mozzachiodi, Riccardo
Learning & Memory, v24 n6 p257-261 Jun 2017
In "Aplysia," long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na[superscript +] and K[superscript +] channels to B51 decreased excitability. In a pharmacologically isolated Na[superscript +] channels environment, LTS training significantly increased B51 firing threshold, compared with untrained controls. Conversely, in a pharmacologically isolated K[superscript +] channels environment, no differences were observed between trained and untrained animals in either amplitude or area of B51 K[superscript +]-dependent depolarizations. These findings suggest that Na[superscript +] channels contribute to the decrease in B51 excitability induced by LTS training.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A