ERIC Number: EJ1006199
Record Type: Journal
Publication Date: 2013-May
Abstractor: As Provided
Activation of BDNF Signaling Prevents the Return of Fear in Female Mice
Baker-Andresen, Danay; Flavell, Charlotte R.; Li, Xiang; Bredy, Timothy W.
Learning & Memory, v20 n5 p237-240 May 2013
There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of "Bdnf" exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal.
Descriptors: Animals, Fear, Females, Gender Differences, Posttraumatic Stress Disorder, Anxiety Disorders, Resistance (Psychology), Learning Processes, Inhibition, Genetics, Biochemistry
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A