Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are…

A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term…

The production effect is a well-established finding: If some words within a list are read aloud, that is, produced, they are better remembered than their silently read neighbors. The effect has been extensively studied with long-term memory tasks. Recently, using immediate serial recall and short-term order reconstruction, Saint-Aubin et al.…

Cognitive models of multimedia learning such as the Cognitive Theory of Multimedia Learning (Mayer 2009) or the Cognitive Load Theory (Sweller 1999) are based on different cognitive models of working memory (e.g., Baddeley 1986) and long-term memory. The current paper describes a working memory model that has recently gained popularity in basic…

Purpose: The purpose of this study was to conceptualize the subtle balancing act between language input and prediction (cognitive priming of future input) to achieve understanding of communicated content. When understanding fails, reconstructive post-diction is initiated. Three memory systems play important roles: working memory (WM), episodic…

We explored the causal role of individual and age-related differences in working memory (WM) capacity in long-term memory (LTM) retrieval. Our sample of 160 participants included 120 children (6-13-years old) and 40 young adults (18-24 years). Participants performed a WM task with images of unique everyday items, presented at varying set sizes.…

Educational researchers have been confronted with a multitude of definitions of task complexity and a lack of consensus on how to measure it. Using a cognitive load theory-based perspective, we argue that the task complexity that learners experience is based on element interactivity. Element interactivity can be determined by simultaneously…

The evolutionarily conserved Elongator Complex associates with RNA polymerase II for transcriptional elongation. Elp3 is the catalytic subunit, contains histone acetyltransferase activity, and is associated with neurodegeneration in humans. Elp1 is a scaffolding subunit and when mutated causes familial dysautonomia. Here, we show that…

From a psycholinguistic perspective of view, there are many cognitive differences that matter to individuals' second-language acquisition (SLA). Although many computer-assisted tools have been developed to capture and narrow the differences among learners, the use of these strategies may be highly risky because changing the environments or the…

Translational research--a bridge between research in more controlled settings and application in more complex contexts--is an essential step in developing effective evidence-based practices. Yet, it is rare. Previous lab-based research has recommended wakeful rest (WR)--a relaxed state of mind in the absence of activity--as a classroom…

Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal…

We segment what we read into meaningful events, each separated by a discrete boundary. How does event segmentation during encoding relate to the structure of story information in long-term memory? To evaluate this question, participants read stories of fictional historical events and then engaged in a postreading verb arrangement task. In this…

Storage of long-term memory requires not only protein synthesis but also protein degradation. In this article, we overview recent publications related to this issue, stressing that the balanced actions of protein synthesis and degradation are critical for long-term memory formation. We particularly focused on the brain-derived neurotrophic factor…

Passively listening to a lecture (deWinstanley & Bjork, 2002), skimming a textbook chapter, or googling for an answer to a homework problem is not conducive to deep and lasting high-order learning. At the same time, presenting complex concepts in problem-based classes might overload students' working memory capacity. Effective student learning…

Reducing sensory experiences during the period that immediately follows learning improves long-term memory retention in healthy humans, and even preserves memory in patients with amnesia. To date, it is entirely unclear why this is the case, and identifying the neurobiological mechanisms underpinning this effect requires suitable animal models,…