As originally formulated by William J. McGuire, Inoculation Theory provided a means of immunizing cultural truisms against the effects of persuasive attacks. Subsequent studies have demonstrated its efficacy in conferring resistance to issues of considerable complexity and controversy. The efficacy of the Inoculation Theory process has been widely attributed to its double-defense action: threat to beliefs motivates subjects to bolster those beliefs, while refutational preemption provides persons with a model for defending the same against attack. Although no research has been conducted to evaluate the utility of Inoculation Theory principles and procedures in considering immunity to matters of religious faith, its success with highly controversial, complex, and personal issues strongly suggests its potential. This research paper consists of seven sections: (1) "Introduction"; (2) "Methodological Considerations"; (3) "Historical Context"; (4) "Early Formulations"; (5) "Challenges to Early Formulations"; (6) "Recent Applications of Inoculation Theory"; and (7) "Conclusion." (Contains 26 references.) (Author/BT)