The intention of this article is to present a year-long interdisciplinary course, Mathematical Models in Chemistry. The course is comprised of eleven units, each of which has both a mathematical and a chemical component. A syllabus of the course is given and the format of the class is explained. The interaction of the professors and the content is demonstrated. The article also discusses the student population, student activities in the course, evaluative measures, and course effectiveness. The article elaborates on three specific units: Models for Drug Concentration, Molecular Symmetry, and Temperature-Humidity Indices. (Contains 2 figures.)