There is a growing literature describing the stressful nature of students' school experience. Previous research has found that racial and ethnic minority groups are particularly subject to high levels of stress due to exposure to violence, pressures due to acculturation, and the schooling process. This is the first study to evaluate effects of the Transcendental Meditation[R] program on psychological distress across diverse racial and ethnic minority student groups. A total of 106 secondary school students (68 meditating and 38 non-meditating students), who completed both baseline and 4-month post-testing, were included. Results indicated reductions in Transcendental Meditation students compared to controls in general psychological distress and anxiety. Within-group effects on depressive symptoms also were observed. Because of the association between psychological distress and both adverse school performance and poor physical and mental health outcomes, it is important for school administrators to implement programs of stress reduction into their schools. (Contains 2 tables.)