Over the past century, much of genetics was deterministic, and feminist researchers framed justified criticisms of genetics research. However, over the past two decades, genetics research has evolved remarkably and has moved far from earlier deterministic approaches. Our article provides a brief primer on modern genetics, emphasizing contemporary evidence for the complex interplay between genes and environment. We focus particularly on the role of gene-environment interactions for gender-imbalanced disorders such as depression. We review research on epigenetics, which is one mechanism by which environment influences gene expression. Modern genetics is not based on a model of genetic determinism; instead, it recognizes the complexity of genetic influences and the nuanced interplay between genes and environment across life span development. Even with the modern genetics approaches, of course, there is still room for criticism and input from gender researchers. We outline methodological and conceptual issues more generally and from a gender researcher's perspective. We argue that, with interdisciplinary collaborations, modern genetics can be integrated into gender research and vice versa in ways that will create progress in both fields.