ERIC Number: EJ1062568
Record Type: Journal
Publication Date: 2015-Jun
Abstractor: As Provided
Brief Report: Phenotypic Differences and Their Relationship to Paternal Age and Gender in Autism Spectrum Disorder
Vierck, Esther; Silverman, Jeremy M.
Journal of Autism and Developmental Disorders, v45 n6 p1915-1924 Jun 2015
Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD.
Descriptors: Autism, Pervasive Developmental Disorders, Differences, Fathers, Age, Sex, Genetics, Intelligence Quotient, Adjustment (to Environment), Symptoms (Individual Disorders), Multiple Regression Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A