In recent years, the concept of post-adoption depression--with both parallels and differences from postpartum depression--has emerged as a salient descriptor of the experience of a significant minority of newly adoptive parents. This article offers a clinical perspective on post-adoption depression through the stories of several families seen in parent-child psychotherapy. Adopting parents face potential challenges from multiple sources, such as personal histories, the context of emotional loss and legal uncertainty, and the demands on reflective function. Increasing awareness of post-adoption depression among providers and families can enhance possibilities for support and appropriate services.