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ERIC Number: EJ935040
Record Type: Journal
Publication Date: 2010
Pages: 10
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0009-2479
Using Aspen to Teach Chromatographic Bioprocessing: A Case Study in Weak Partitioning Chromatography for Biotechnology Applications
Evans, Steven T.; Huang, Xinqun; Cramer, Steven M.
Chemical Engineering Education, v44 n3 p198-207 Sum 2010
The commercial simulator Aspen Chromatography was employed to study and optimize an important new industrial separation process, weak partitioning chromatography. This case study on antibody purification was implemented in a chromatographic separations course. Parametric simulations were performed to investigate the effect of operating parameters (e.g., feed load, salt concentration) on the productivity and yield of this separation process. The course project served to teach students basic simulator operation, apply course material to a separation challenge from the biotechnology industry, and open-ended problem exploration for process optimization.
Chemical Engineering Education, Chemical Engineering Division of ASEE. P.O. Box 142097, Gainesville, FL 32614. Tel: 352-392-0861; Fax: 352-392-0861; e-mail: cee@che.ufl.edu; Web site: http://cee.che.ufl.edu/index.html
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A