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Leong, Jhaque; Ackroyd, Nathan C.; Ho, Karen – Journal of Chemical Education, 2014
The synthesis of N-methoxycarbonyl-2-imidazolidone, an analogue of biotin, was conducted by organic chemistry students and confirmed using FT-IR and H NMR. Spectroscopy students used FT-IR to measure the rate of hydrolysis of the product and determined the rate constant for the reaction using the integrated rate law. From the magnitude of the rate…
Descriptors: Science Instruction, Science Laboratories, Spectroscopy, Kinetics
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Millar, Thomas James; Knighton, Ronald; Chuck, Jo-Anne – Biochemistry and Molecular Biology Education, 2012
Immunological detection of proteins is an essential method to demonstrate to undergraduate biology students, however, is often difficult in resource and time poor student laboratory sessions. This method describes a failsafe method to rapidly and economically demonstrate this technique using biotinylated proteins or biotin itself as targets for…
Descriptors: Biology, Scientific Concepts, Science Process Skills, Molecular Biology
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Polyak, Steven – Teaching Science, 2014
Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…
Descriptors: Biology, Guides, Molecular Biology, Physical Sciences
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Mascotti, David P.; Waner, Mark J. – Journal of Chemical Education, 2010
A protein-ligand binding, guided-inquiry laboratory project with potential application across the advanced undergraduate curriculum is described. At the heart of the project are fluorescence and spectrophotometric assays utilizing biotin-4-fluorescein and streptavidin. The use of the same stock solutions for an assay that may be examined by two…
Descriptors: Chemistry, Science Instruction, Spectroscopy, Molecular Structure
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Correiro, Elizabeth E.; Griffin, Leanne R.; Hart, Peter E. – American Biology Teacher, 2008
A laboratory exercise is presented that incorporates constructivist principles into a learning experience designed for upper-level university biology courses. The specific objectives for this exercise are as follows: (1) To introduce students to cancer biology and to the regulation of programmed cell death as part of the cell cycle; (2) To engage…
Descriptors: Constructivism (Learning), Research Design, Inquiry, Cooperative Learning
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Landman, A. D.; Landman, N. N. – Journal of Chemical Education, 1976
Describes a biochemistry experiment that illustrates the methodology of affinity chromatography by attaching avidin, a glycoprotein in egg white, to a Sepharose matrix in order to bind biotin-containing proteins. (MLH)
Descriptors: Biochemistry, Chemical Analysis, Chemistry, Chromatography
Schiller, M. Rosita, Ed.; And Others – 1985
The following papers are included: "Consortia and Collaborative Research: Getting Started" (Hansen); "Coordination of the Health Care System in the State of Michigan" (Burian, Boyden, Herbert); "Health Promotion and Disease Prevention in Allied Health" (Doiron, Douglas); "Interprofessional Collaboration in the Analysis of Public Policy" (Dunn);…
Descriptors: Allied Health Occupations Education, Cooperative Planning, Educational Needs, Educational Research