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ERIC Number: EJ1123411
Record Type: Journal
Publication Date: 2016-Dec
Pages: 5
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory
Streu, Craig N.; Reif, Randall D.; Neiles, Kelly Y.; Schech, Amanda J.; Mertz, Pamela S.
Journal of Chemical Education, v93 n12 p2084-2088 Dec 2016
Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive; Guides - Classroom - Teacher
Education Level: Higher Education; Postsecondary Education
Audience: Teachers
Language: English
Sponsor: N/A
Authoring Institution: N/A