The Boston Opportunity Agenda is a partnership among the City of Boston, Boston Public Schools, the University of Massachusetts Boston, and the city's leading public charities along with many other local foundations and philanthropists. The partnership's goal is to use its members' varied resources and expertise in a unified manner to improve the postsecondary, career, and life outcomes for all of Boston's children. With this larger goal in mind, the Boston Opportunity Agenda undertook a project in 2016 to identify and develop a set of college and career readiness indicators, for use by stakeholders in Boston's K-12 institutions to guide future policy and practice. This project is driven by the necessity of having a post-secondary degree to achieve career success and life-long opportunities in today's knowledge economy. In Boston specifically, half of all job vacancies required at least an associate's degree, at the time of this project's undertaking. In addition, a typical bachelor's degree holder will earn $1 million more than a high-school dropout over the course of a lifetime. With only 36.5 percent of all Boston Public Schools graduates obtaining a post-secondary credential within six years of graduating high school, there is a stark need in Boston to ensure that more of its youth achieve a post-secondary degree and the life-long opportunities that come with it. Further, of those high school graduates who do enroll in post-secondary schooling, 36 percent require at least one remedial class and only 51.3 percent obtain a credential within six years of graduating high school. These statistics suggest that even when students earn a high school diploma, many are still doing so without the skills, knowledge, and attributes necessary to achieve post-secondary success. By identifying a valid set of indicators for post-secondary success, local practitioners can determine which specific criteria their students must meet prior to completing high school in order to be prepared for post-secondary success and use those indicators to recognize which of their students are currently off-track to achieving those goals.