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Direct linkChen, Jie; Li, Xinying; McGue, Matt – Journal of Child Psychology and Psychiatry, 2013
Background: Confounding introduced by gene-environment correlation (rGE) may prevent one from observing a true gene-environment interaction (G × E) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the…
Descriptors: Depression (Psychology), Symptoms (Individual Disorders), Foreign Countries, Adolescents
Papaleo, Francesco; Silverman, Jill L.; Aney, Jordan; Tian, Qingjun; Barkan, Charlotte L.; Chadman, Kathryn K.; Crawley, Jacqueline N. – Learning & Memory, 2011
BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher…
Descriptors: Animals, Seizures, Genetics, Short Term Memory
Liu, Richard T. – Child Abuse & Neglect: The International Journal, 2010
Objectives: Although there is increasing research exploring the psychosocial influences and biological underpinnings of bipolar disorder, relatively few studies have specifically examined the interplay between these factors in the development of this illness. Social-biological models within a developmental psychopathology perspective are necessary…
Descriptors: Mental Disorders, Psychopathology, Children, Genetics
Gibb, Brandon E.; Grassia, Marie; Stone, Lindsey B.; Uhrlass, Dorothy J.; McGeary, John E. – Journal of Abnormal Child Psychology, 2012
The goal of the current study was to examine the role of brooding rumination in children at risk for depression. We found that children of mothers with a history of major depression exhibited higher levels of brooding rumination than did children of mothers with no depression history. Examining potential mechanisms of this risk, we found no…
Descriptors: Children, Mothers, Depression (Psychology), Parent Child Relationship
