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Showing 1 to 15 of 38 results Save | Export
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Cohen-Gilbert, Julia E.; Stein, Elena R.; Gunnar, Megan R.; Thomas, Kathleen M. – Journal of Early Adolescence, 2018
This study investigated whether brain-derived neurotrophic factor (BDNF) genotype moderated inhibitory control during an emotionally valenced task in a sample of internationally adopted adolescents (N = 109, ages 12-13 years) who spent their early years in institutional care. Participants were genotyped for the Val66Met polymorphism of the BDNF…
Descriptors: Stress Variables, Genetics, Inhibition, Task Analysis
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Dulka, Brooke N.; Ford, Ellen C.; Lee, Melissa A.; Donnell, Nathaniel J.; Goode, Travis D.; Prosser, Rebecca; Cooper, Matthew A. – Learning & Memory, 2016
Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increases the expression of mBDNF, but not proBDNF, in…
Descriptors: Brain, Memory, Brain Hemisphere Functions, Social Behavior
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Vedder, Lindsey C.; Savage, Lisa M. – Learning & Memory, 2017
Thiamine deficiency (TD), commonly associated with chronic alcoholism, leads to diencephalic damage, hippocampal dysfunction, and spatial learning and memory deficits. We show a decrease in the magnitude of long-term potentiation (LTP) and paired-pulse facilitation (PPF) at CA3-CA1 synapses, independent of sex, following diencephalic damage…
Descriptors: Brain, Animals, Nutrition, Neurological Impairments
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Zhang, Yili; Smolen, Paul; Alberini, Cristina M.; Baxter, Douglas A.; Byrne, John H. – Learning & Memory, 2016
Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins…
Descriptors: Inhibition, Animals, Animal Behavior, Brain Hemisphere Functions
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Hinton, Elizabeth A.; Wheeler, Marina G.; Gourley, Shannon L. – Learning & Memory, 2014
An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited--or "habitual"--qualities that are resistant to change. We show that selective knockdown of prelimbic…
Descriptors: Cocaine, Goal Orientation, Reinforcement, Stimulants
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Baker-Andresen, Danay; Flavell, Charlotte R.; Li, Xiang; Bredy, Timothy W. – Learning & Memory, 2013
There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the…
Descriptors: Animals, Fear, Females, Gender Differences
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Gomes da Silva, Sérgio; de Almeida, Alexandre Aparecido; Fernandes, Jansen; Lopim, Glauber Menezes; Cabral, Francisco Romero; Scerni, Débora Amado; de Oliveira-Pinto, Ana Virgínia; Lent, Roberto; Arida, Ricardo Mario – Online Submission, 2016
Clinical evidence has shown that physical exercise during pregnancy may alter brain development and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell…
Descriptors: Mothers, Pregnancy, Exercise, Brain Hemisphere Functions
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Endres, Thomas; Lessmann, Volkmar – Learning & Memory, 2012
Beyond its trophic function, the neurotrophin BDNF (brain-derived neurotrophic factor) is well known to crucially mediate synaptic plasticity and memory formation. Whereas recent studies suggested that acute BDNF/TrkB signaling regulates amygdala-dependent fear learning, no impairments of cued fear learning were reported in heterozygous BDNF…
Descriptors: Fear, Learning, Brain, Animals
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Kirtley, Anne; Thomas, Kerrie L. – Learning & Memory, 2010
We have previously reported that the reconsolidation and extinction of hippocampal-dependent contextual fear memory can be initiated by a single context conditioned stimulus (CS) presentation of either short or long duration, and that both processes require protein synthesis in this brain region. Furthermore, reconsolidation depends on Zif268…
Descriptors: Stimuli, Memory, Brain, Fear
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Olsen, Ditte; Kaas, Mathias; Schwartz, Ole; Nykjaer, Anders; Glerup, Simon – Learning & Memory, 2013
BDNF-induced signaling is essential for the development of the central nervous system and critical for plasticity in adults. Mature BDNF signals through TrkB, while its precursor proBDNF employs p75[superscript NTR], resulting in activation of signaling cascades with opposite effects on neuronal survival, growth cone decisions, and synaptic…
Descriptors: Anxiety, Fear, Genetics, Animals
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Papaleo, Francesco; Silverman, Jill L.; Aney, Jordan; Tian, Qingjun; Barkan, Charlotte L.; Chadman, Kathryn K.; Crawley, Jacqueline N. – Learning & Memory, 2011
BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher…
Descriptors: Animals, Seizures, Genetics, Short Term Memory
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Kristinsson, Sigfus; Yourganov, Grigori; Xiao, Feifei; Bonilha, Leonardo; Stark, Brielle C.; Rorden, Chris; Basilakos, Alexandra; Fridriksson, Julius – Journal of Speech, Language, and Hearing Research, 2019
Purpose: The brain-derived neurotrophic factor (BDNF) gene has been shown to be important for synaptic plasticity in animal models. Human research has suggested that BDNF genotype may influence stroke recovery. Some studies have suggested a genotype-specific motor-related brain activation in stroke recovery. However, recovery from aphasia in…
Descriptors: Brain, Aphasia, Brain Hemisphere Functions, Neurological Impairments
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Fortress, Ashley M.; Kim, Jaekyoon; Poole, Rachel L.; Gould, Thomas J.; Frick, Karyn M. – Learning & Memory, 2014
Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone acetylation has been associated with age-related memory decline in male rodents, little is known about whether histone acetylation is altered by aging in female rodents. In young female mice, the ability of 17ß-estradiol…
Descriptors: Biochemistry, Memory, Animals, Recognition (Psychology)
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Saghazadeh, Amene; Rezaei, Nima – Journal of Autism and Developmental Disorders, 2017
Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at…
Descriptors: Meta Analysis, Brain Hemisphere Functions, Patients, Control Groups
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Yeh, Ting-Kuang; Hu, Chung-Yi; Yeh, Ting-Chi; Lin, Pei-Jung; Wu, Chung-Hsin; Lee, Po-Lei; Chang, Chun-Yen – Brain and Cognition, 2012
The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single…
Descriptors: Memory, Genetics, Neurological Organization, Auditory Perception
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