This quantitative cross-sectional study examines the overall attitudes of a sample of Arab Americans toward persons with disabilities. A convenience sample of 372 Arab Americans was recruited from various not-for-profit Arab organizations within 30 States. Participants in the study completed an online self-administered (Qualtrics) survey that included a sociodemographic questionnaire and three validated measures: Vancouver Index of Acculturation-Modified Arab Version (VIA-A; Amer, 2005), Contact with Disabled Persons (CDP) scale (Yuker & Hurley, 1987), and Scale of Attitudes Toward Disabled Persons (SADP; Antonak & Livneh, 1989). Data were analyzed using both bivariate and multivariate techniques including Pearson's r correlation, t-test, one-way ANOVA, and hierarchical regression analysis. The results provide evidence to support strong relationships between some sociodemographic characteristics and people who identify strongly with mainstream American culture, and more overall, general, and positive contacts were significantly correlated with more favorable attitudes toward persons with disabilities. The ANOVA test (F = 21.216, p <0.05) was statistically significant. Overall, the hierarchical regression model shows more favorable overall attitudes of Arab Americans toward persons with developmental disabilities are accounted by length of stay (ß = -0.30; t = -5.856, p < 0.05), being Christian (ß = 0.12; t = 2.314, p < 0.05), mainstream identification with American culture (ß = -0.25; t = -4.772, p < 0.05), and positive contact (ß = -0.20; t = -4.075, p <0.05). These four variables accounted for 9% (R = 0.30), 1% (R = 0.32), 6% (R = 0.40), and 4% (R = 0.44) of the variance in overall attitudes respectively. Thus, 80% of variance in overall levels of attitudes is unaccounted for the future research. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]