The role of culture in children's development and in early intervention/early childhood special education practices has been ignored in the United States until recent years (Coll & Magnuson, 2000), with the values of the Anglo American culture dominating. Among the cultural characteristics of families, parental perceptions in connection with the development and disability of their children may have the greatest effect on EI/ECSE practices, as parental perceptions are considered key factors in interactions between parents and EI/ECSE professionals. This article examines studies that have focused on parental perceptions on the nature, causation, and treatment of disability among families of children with disabilities across varied traditional cultural groups, including Mexican American, Chinese American, Arab, and Jewish communities.