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ERIC Number: EJ951895
Record Type: Journal
Publication Date: 2012-Jan
Pages: 11
Abstractor: As Provided
ISSN: ISSN-1087-0547
Reading Performance as a Function of Treatment with Lisdexamfetamine Dimesylate in Elementary School Children Diagnosed with ADHD
Wigal, Sharon B.; Maltas, Stephanie; Crinella, Francis; Stehli, Annamarie; Steinhoff, Kenneth; Lakes, Kimberley; Schuck, Sabrina
Journal of Attention Disorders, v16 n1 p23-33 Jan 2012
Background: Medication treatment studies of ADHD have typically not assessed effects on reading performance, although reading difficulties frequently co-occur in children with ADHD. The current study characterizes the effects of lisdexamfetamine dimesylate (LDX; Vyvanse[R], Shire US Inc.), at peak efficacy, on reading performance in children with ADHD. Method: Children (ages 6-12; N = 26) with ADHD enrolled in a modified laboratory school study with an open-label, dose-optimization phase of LDX (30-70 mg/d). The Gray Oral Reading Test-4 (GORT-4) with measures of rate, accuracy, and comprehension was administered at baseline and 3-4 hr postdose, following 4 to 5 weeks of optimal dose titration. Results: Treatment reduced ADHD symptoms. Reading rate was improved, especially among children with higher verbal fluid reasoning without additional symptoms of neurodevelopmental delay. No differences were observed for reading accuracy or comprehension. Conclusion: Endophenotypical profiles may predict drug effects in specific skill areas, such as reading rate. (Contains 3 figures and 5 tables.)
SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Elementary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: California
Identifiers - Assessments and Surveys: Gray Oral Reading Test; Kaufman Brief Intelligence Test; Wechsler Intelligence Scale for Children