This article discusses the theoretical framework, instructional design, formative assessment results, capacity for national distribution, and generalization of the Blending Assessment with Instruction Program (BAIP) model to other content areas such as science. The BAIP, developed and validated at the University of Kansas, employs technology to align instruction in mathematics with National Council of Teachers in Mathematics Standards. BAIP consists of three sets of Web-based resources that are available 24/7 for students and teachers in grades three through high school. Resources include 276 self-contained mathematic lessons structured around five frameworks (i.e., contextual, teaching, lesson, application, and extension); 417 independent online tutorials that provide immediate feedback to students; and a data reporting system that provides teachers with immediate feedback on student performance to facilitate instructional decision making. The materials are suitable for all learners, with particular emphasis on students with disabilities. Two years of field testing have been completed. (Contains 5 tables and 2 figures.)