The purpose of the study is to determine the effect of the science-technology-engineering and mathematics integrated argumentation based science learning approach on the resolution of daily life problems and the change of high-level thinking skills. Mixed method was used in the research. Quantitative data were collected with a single group pre-test-post-test experimental design. Qualitative data were gathered with document review and daily life problem determination form. The data presented with descriptive and content analysis, frequency, percentage and Wilcoxon signed rank test techniques. A homogeneous sample was used in the study and was carried out with a randomly chosen class in a mountain village secondary school. From the analysis of the daily life problems before and after the implementation, it was observed a positive change in the participants thinking on the identification and solution of daily life problems. Also, the unresolved problem factor determined for the land factor in hazelnut transportation is removed after the application.