This brief first describes individual interventions that CREATE researchers tested in middle school science, social studies, and language arts classrooms with English language learners over the course of the 2005-2009 school years. The brief then explains how the SIOP Model was used as a professional development framework to unite the separate research studies into a school-wide, comprehensive intervention that was implemented in the 2009-2010 and 2010-2011 school years to support English language learners across the core content areas.