The purpose of this study is to explore factors that affect institutional performance of Wolaita Sodo University. The study has identified middle level manager's perceptions toward institutional performance to indicate the key factors that seem to affect the performance of the university. Data were collected using structured questionnaires and interview. The collected data were analyzed using simple quantitative analysis. The finding of the study revealed that factors that influencing the institutional performance are leadership experience, academic rank of the managers, applied policy and procedures, making professional learning community and ensuring efficient financial management and accountability. Finally, recommendations were forwarded based on the major finding in order to improve Institutional performance like as officials should updates its policies and procedures through participation of the whole community, professional pathways should include professional learning priorities, financial resource allocation and distribution should be made to each unit in accordance with aligned work and activities, accessing training regarding educational leadership and promoting the staff to engaged in research and community service and publish on reputable journals.