In the rapidly developing age of technology, the contribution of using multimedia-supported instructional materials in the field of teaching technologies to science education has been increasing steadily. The purpose of this research is to compare the multimedia learning instructional materials prepared according to the 7E learning model and the students' academic success and the effect on the reminiscence of the learned knowledge in the science course described using traditional methods and models. In this research, a quadruple pattern of solomon was used as a semi-experimental design. As a data collection tool, the Matter's Change Unit Success Test was used. The research was conducted in fall semester of 2014-2015 academic year and on 92 fifth grade students. Experimental groups were given instructional materials prepared according to 7E model with multimedia support and control groups were taught with traditional method. There was no statistically significant difference in the pre-test scores of the experimental-1 and control-1 groups according to the independent t-test results in the applied success test but there was a statistically significant difference in favor of the experimental groups according to the post-test and retention test scores. According to the analyzed results; There is a statistically significant difference between the post-test and retention test scores of the experimental groups. There is also a statistically significant difference between the post-test and retention test scores of the control groups. But this difference is in favor of experimental groups. According to the results of the study, it can be said that the learning material prepared according to the multimedia supported 7E model influences the academic achievement positively and the learned information is more memorable.