While many in the field of teaching grapple with the revisions that come with a growing decentralization of standards-based reform, teacher learning and understanding of college- and career-readiness (CCR) standards and revisions is critical to successful implementation. Even when fully supported and focused on implementing standards in the classroom, teachers often face challenging work conditions that stymie their best efforts to implement standards-based reform. Based on select questions from a spring 2016 survey administered to a representative sample consisting of district administrators, principals, and teachers in Kentucky, Ohio, and Texas, the Center on Standards, Alignment, Instruction, and Learning (C-SAIL) uncovered some common challenges facing teachers, principals, and districts. To measure these challenges, C-SAIL provided a list of 10 school, classroom, and student challenges and asked respondents to rate them as either not a challenge, a minor challenge, a moderate challenge, or a major challenge. This brief report describes the top five reported challenges among teachers.