Introduction: The low productivity that prevailing in recent years in Higher Education requires urgently institutional responses aimed to improving quality of university education contributing to the development among students of key competences for lifelong learning. In this sense, the aim of this research was to explore the effects of an intervention program, based on service-learning and peer mentoring methodologies, to enhance social skills and the learn to learn skill of university students. Method: The sample was composed of 78 university students of 5 degrees related to the teaching profession of the University of Huelva (Spain). The methodological design adopted was quasi-experimental pretest-posttest, using standardized tests to evaluate the dependent variables. The intervention consisted of 481 mentoring sessions, 423 individual and 58 in group, among the university students, as mentors, previously trained in 3 sessions of training, and students in Compulsory Education. These sessions spread throughout the second and third quarters of the school year 2013/2014 during out of school time, a weekly mentoring session among the couple of mentors with their mentee lasted for 90 minutes each. Results: The results show statistically significant differences in favour of the posttest phase in social skills and strategies for learning and motivation of the participants. Discussion and Conclusion: These results agree largely whit the empirical evidences from specialized literature show when service-learning and peer mentoring methodology are used as the basis for an intervention program.