Objective: We explored the relationship between acculturation and parenting stress among parents of children with developmental delays (DD) and investigated family support as a potential moderator. Methods: Participants included 99 parents of young children with DD. Standardized measures were used to evaluate the variables of interest and a multiple linear regression analysis was employed to test the moderation effect. Results: Our results indicated that the relationship between acculturation and parenting stress depended on the level of family support. More specifically, low levels of acculturation were associated with increased parenting stress at high levels of family support but not low levels of family support. Conclusions: Minority parents of children with DDs may be at risk for especially high levels of parenting stress due to the additive stress of adapting to a new culture and parenting a child with special needs. Implications for intervention and future research are discussed.