This study intends to elaborate upon difficulties in career decisions of high school students with different locus of control. 9th, 10th, 11th and 12th grade students aged 14-19, 282 (%55.4) females, 227 (%44.6) males totaling 509 participants involved in research located in the south of Turkey. Career Decision-Making Difficulties Questionnaire (CDDQ) and Rotter Internal-External Locus of Control Scale (RIEFCS) were used to collect data. One-way analysis of variance was conducted to compare the participants' career decision-making difficulties in accordance with the locus of control. The findings indicate that total points obtained from the scale of career decision-making difficulties of the participants with external locus of control and lack of information of the scale with inconsistent information sub-dimensions have a higher score average than students with internal locus of control. Individuals with external locus of control experienced more difficulty in the process of decision-making due to the lack of necessary information or inconsistent information. This study contributes to practitioners working in the field of career for theory or application.