In today's digital age, Web 2.0 tools such as VoiceThread allow users to integrate images, voices, and responses within one digital platform, providing students with the opportunity to add another layer of meaning to their texts. We conducted this research to expand our understanding of the processes necessary for integrating digital tools into instruction. Specifically, we sought to explore the instructional uses of VoiceThread within an elementary classroom, a middle school classroom, and a high school classroom. We studied teachers' experiences and perceptions when using this tool in their classrooms. We believe our findings will contribute to the continuously evolving knowledge base of instructional practices that can be used to expand students' 21st-century literacy skills.