The technological advancements for teaching and learning sciences for health science students are embedded in the Thalluri-Penman Good Practice Model, which aims to improve the learning experiences of science students and increase student retention and success rates. The model also links students from urban and rural areas, studying both on-and off-campus, with the university campus and with co-students and is primarily structured to boost students' confidence in studying sciences. This paper investigates the introduction of online initiatives, namely, electronic learning communities, online self-assessments, virtual classroom, and the inclusion of social media Facebook to offer practically oriented science learning to urban and regional science students. It examines the issues surrounding the implementation of these technological innovations by identifying the perceptions of the students about their use, illuminating their impact on students, and clarifying the practical issues encountered in the application of these online initiatives. A descriptive analytical approach was used to explore the experiences of students in the use of these innovations. Findings of the evaluations show that the technology exemplified in this paper provides: an approximation of face-to-face lecturing when it is not possible for a lecturer to be at the same site as the class; enhance communication between students and lecturers; and help students access, collaborate and interact with each other. The use of technology that is carefully considered in each stage of the program has been shown to enhance the quality of university teaching and learning, allowing students' greater accessibility, flexibility and interaction.