Student engagement in the classroom is important for the achievement of learning outcomes. As digital technologies continue to improve and become more economically viable to students and schools, many schools have adopted the Student Response System (SRS) with the purpose of increasing student engagement. In an SRS, students answer the teacher's questions using handheld devices, called "clickers", or more recently, their own mobile phones via the Internet. The SRS gives the teacher an immediate assessment of the understanding of the students collectively and individually. However, there is very little research on mobile phone-based SRS using the Internet. Furthermore, the research on student perceptions using a cross-cohort approach was non-existent. Therefore, the authors carried out an exploratory study to fill in this gap. In this study, 274 students, who were at different stages of study at a university, were taught using a mobile phone-based SRS and a polling web site. A subsequent online survey based on the Technology Acceptance Model was conducted. It was found that the students showed high perceived usefulness (PU) and high perceived ease of use (PE) on the SRS, despite their differences in their stages of study. This study showed that the mobile-phone based SRS is feasible in the university's environment. This study also found internally reliable constructs for measuring the PU and PE in the TAM.