The future of distance and Web-enhanced education and the use of technology are becoming more advantageous to a growing population. Nursing education has been encouraged to incorporate these teaching-learning methods. Changes in nursing education and the teaching-learning environment have the potential to challenge the preservation of nursing standards related to safe patient care. The purpose of this qualitative case study was to explore lessons learned from the perspective of the nursing students and educators participating in these Web-enhanced teaching-learning strategies. Teaching-learning strategies that are perceived as satisfactory in the outcome achievements associated with the application of safe patient-centered care were investigated. The unit of analysis involved in this study is a School of Nursing located in a large public university. This School of Nursing allows working Associate Degree Registered Nurses to benefit from prior education and experience while achieving their post licensure Bachelor of Science in Nursing. Three sources of data, including a retrospective review of the past 3 years of student evaluative qualitative remarks at exit of the program, open-ended face-to-face interviews with educators directly involved in this teaching methodology, and open-ended face-to-face interviews with students enrolled in this Web-enhanced program were collected. These three sources of data were analyzed inductively to generate findings. The students and educators indicated the teaching-learning strategies used in this Web-enhanced program were satisfactory in promoting achievement of safe patient care outcomes through-out the teaching-learning process. Those most satisfactory include the flexibility of the Web-enhanced approach, multi-Media learning experiences, online and in-class discussions, and application based scenarios. Recommendations are to continue use of these teaching-learning strategies while further exploring the significance of increased face-to-face and hands on experiences and to seek ways to overcome the hindrance that technology can sometimes create. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]