Social networking sites are globally popular. In the United States, these types of sites are perceived positively by users and used at high rates, which has likely yielded personal health behavior displays such as substance abuse and depression. Due to possible cultural influence present on these sites, it remains unknown if SNS could be utilized towards identifying health-related displays internationally, specifically in resource-limited countries like Ecuador. The study aimed to explore the perceptions and use of social networking sites in the United States and Ecuador. Perceptions and use were examined through interviews in the US and paper surveys in Ecuador. Interviews and surveys addressed identical items. US university students reported more positive views of social networking sites and more social networking site use than Ecuadorian students, but reported internet use was similar. Thus, US and Ecuadorian students view and use social networking sites differently. These differences illustrate that cultural considerations should be taken when using social networking sites in global intervention research, as well as the potential for this area of research.