An e-TextBook can serve as an interactive learning environment (ILE), facilitating more effective teaching and learning processes. In this paper, we propose the novel concept of an EPUB 3-based Hybrid e-TextBook, which allows for interaction between the digital and the physical world. In that regard, we first investigated the gap between the expectations of teachers with respect to e-TextBook functionalities, on the one hand, and the ILE functionalities offered by e-TextBooks, on the other hand. Next, together with teachers, we co-designed and developed prototype EPUB 3-based Hybrid e-TextBooks that make it possible to connect their learning content to smart devices in classrooms, leveraging both digital publishing and Semantic Web tools. Based on experimentation with our prototype Hybrid e-TextBooks, we can argue that a semantically enriched EPUB 3-based Hybrid e-TextBook is able to act as a comprehensive ILE, providing the tools needed by teachers in smart classrooms. Furthermore, expert observations and Smiley o'meter results demonstrate an effective impact on student cognition and motivation.