Background: African American women (AAW) are in a unique position to be recruited into mobile (mHealth) weight management research and programs due to their high rates of obesity and their high ownership of smartphones. Aim: This study examined smartphone usage, social media engagement, and willingness to participate in mHealth weight management among AAW in north-central Florida, United States. Methods: A self-administered survey was completed by a convenience sample of 425 smartphone owners in north-central Florida. Results: Mean age was 34.84 ± 13.74, with age distribution of 18 to 29 (45%), 30 to 50 (39%), and 51+ years (17%). Mean body mass index was 29.52 ± 8.18. Most used smartphones to access the Internet daily and were engaged with eight social media sites, such as Facebook (85%), YouTube (75%), and Google+ (57%). Compared to those 51+, those 18 to 29 were more likely to use YouTube (odds ratio [OR] = 2.52, p = 0.017) and Instagram (OR = 10.90, p < 0.0001), but they were less likely to use Google+ (OR = 0.40, p = 0.009). Compared to those 51+, those 30 to 50 were more likely to use Instagram (ß = 1.28, OR = 3.61, p = 0.014) and Facebook (ß = 1.04, OR = 2.84, p < 0.006). Most were willing to participate in research that used text messages (73%), smartwatches/fitness trackers (69%), and smartphone apps (68%). Compared to those 51+, women 18 to 29 were more likely to report willingness to use a smartphone app (OR = 5.45, p < 0.0001) as were those 30 to 50 (OR = 3.14, p < 0.0001). Conclusion: AAW's high ownership of smartphones, use of mHealth apps and tools, and willingness to participate in mHealth research has the potential to curb the obesity epidemic by participating in mHealth weight management programs and research.