This study evaluated the quality of the research and evidence base for using response cards to increase opportunities to respond (OTR) for students with and without disabilities at the elementary level (i.e., kindergarten through Grade 5). Using quality indicator criteria for single-case research, six single-case studies investigating response cards were analyzed. Based on an analysis of quality indicators, results established the use of response cards as an evidence-based practice with a moderate level of evidence. Implications for future research and practice are discussed.