A proper use of e-collaboration technologies in the teaching/learning process is provided by varied cooperative networks, which penetrate teachers' and students' activity more thoroughly with the availability of broadband services. However, the successful use of e-collaboration technologies in teaching/learning activity within a multicultural environment requires that the key factors have to be considered. Aim of the following paper is to identify and to analyze these key factors in the use of e-collaboration technologies in teaching/learning activity. The meaning of the key concepts of e-collaboration technologies, collaboration and factors is studied within the search for factors affecting the use of e-collaboration technologies. The results of the paper reveal the factors forming a successful use of e-collaboration technologies in teaching/learning activity to become more mobile, to learn from the experiences of others and to work in a qualitative way. (Contains 2 figures.)