The availability of effective research-based interventions and practices within schools is a growing concern within the field of education. There remains a lack of interventions that have been fully evaluated for use within schools and by school personnel, particularly in the area of social skills interventions. Understanding the need for social skills interventions and the long-term impact of not receiving appropriate programming is clear. Less is established on how to define the specific need and appropriate manner by which to match intervention to those needs within school settings. This article provides a six-step decision-making process designed to support educators in determining best practice social skills instruction.