This investigation examined the extent to which homophobic victimization predicted multiple indicators of psychological and social distress for middle school students (n = 143) during a 1-year assessment period. Hierarchical regression analyses indicated that homophobic victimization significantly predicted increased anxiety and depression, personal distress, and lower sense of school belonging in males and higher levels of withdrawal in females after controlling for previously reported levels of each variable. Results suggest that being the target of homophobic victimization has significant psychological and social consequences for students, although differentially for males and females. Although use of such content may occur within peer groups and appear to be harmless banter between friends, teachers and administrators should intervene during these occurrences, and school policies and programming should specifically address and seek to decrease this social problem. (Contains 3 tables.)